Efficacy of Octreotide for the Treatment of Acute Adhesive Intestinal Obstruction

Objective: To investigate the efficacy of octreotide for the treatment of acute adhesive intestinal obstruction.Methods: 70 patients with acute adhesive intestinal obstruction were randomly divided into observation group and control group with each of 35 cases. Control group were treated with decompression, enemas, rehydration and anti-infection drugs and such as conventional treatment. On this basis, observation group was added with octreotide (somatostatin analogue)0.1mg subcutaneously, once every 8h, treatment for 72 h. Abdominal pain score, pain relief time, the amount of decompression, anal exhaust time to restore, establish supine abdominal plain film and clinical remission were observed. Results: 34 patients (97.1%) of the observation group got clinical remission, which was significantly higher than 28 cases (80.0%) of the control group (P0.05). Compared with the control group, the abdominal pain score of the observation group was significantly decreased at 1 and 2 days after treatment (P0.01), and pain relief time was significantly shorter (P0.01), gastrointestinal decompression volume decreased significantly at 2 and 3 days after treatment(P0.01), recovery time was significantly shorter (P0.01). Conclusion: Based on the conventional treatment, somatostatin can significantly improve the clinical symptoms and efficacy for the treatment of acute adhesive intestinal obstruction.