Clinical significance of serum squamous cell carcinoma related antigen detection in advanced lung squamous cell carcinoma

Objective To investigate the clinical value of serum squamous cell carcinoma related antigen(SCC-Ag) detection in advanced lung squamous cell carcinoma. Methods Among the study subjects as 80 lung cancer patients, there were 50 cases with squamous cell carcinoma, 14 cases with adenocarcinoma, 11 cases with small cell lung cancer(SCLC), and 5 cases with large cell lung cancer(LCLC). Another 45 patients with benign lesion were selected as well. All the patients received SCC-Ag detection. Results The positive rate of lung squamous cell carcinoma was 68.00%, that of lung adenocarcinoma was 14.29%, that of SCLC was 18.18%, that of LCLC was 20.00%, and that in the control group was 2.22%. The result of dynamic observation before and after surgery showed that SCC-Ag turned to be negative within 3 d after surgery, and it had statistically significant difference with other methods(P0.05). Conclusion SCC-Ag is the specific marker for lung squamous cell carcinoma, and it provides an important reference index for the prediction of surgery effect and long-term prognosis for patients.