The Clinical Performance of SCC-Ag in Squamous Cell Carcinoma and Related Benign Diseases

To investigate the clinical performance of squamous cell carcinoma antigen(SCC-Ag) as a tumor marker in the auxiliary diagnosis and clinical monitor of squamous cell carcinoma and related benign diseases,and to explore the relationship between serum SCC-Ag level and the clinical stage,pathological grade of cervical squamous cell carcinoma,the serum level of SCC-Ag in 167 patients with squamous cell carcinoma,96 patients with related benign diseases and 96 healthy individuals were measured by Microparticle Enzyme Immunoassay(MEIA).The results showed that the serum level of SCC-Ag in patients with squamous cell carcinoma was significantly higher than that in patients with related benign diseases and healthy controls(P0.01).The serum SCC-Ag showed a sensitivity of 61.1% and a specificity of 91.67% for diagnosis of squamous cell carcinoma.The area under the ROC curve(AUC) was 0.825,which revealed high accuracy in the diagnosis of squamous cell carcinoma and can be used as an important diagnostic basis.The serum SCC-Ag levels was positively correlated with positive rate of squamous cell carcinoma and its clinical stage,had but no correlation with the pathologic grade.The serum level of SCC-Ag had significant differences between patients with benign diseases and healthy controls(P0.05).The serum SCC-Ag has the good clinical values in the differential diagnosis of squamous cell carcinoma and benign diseases.It can also be used as a specific tumor marker for auxiliary diagnosis of squamous cell carcinoma of the lung,the cervix and the esophagus.