Pharmacokinetics of ziprasidone tablet in healthy subjects

AIM: To study the pharmacokinetics of a single oral dose of ziprasidone in 9 healthy male volunteers. METHODS: A single dose of 20 mg of ziprasidone tablet was administed. The blood samples were taken at 1.0,2.0,3.0,4.0,5.0,6.0,7.0,8.0,9.0,10.0,12.0,14.0 h after oral administration. The concentrations of ziprasidone in serum were determined by HPLC method,the pharmacokinetic parameters were calculated with 3P97 program. RESULTS: The concentration-time curves of ziprasidone fitted to one-comprartment model,with cmax as(176 ± s 86) μg·L-1 ,tmax as(4.3 ± 0.9) h,t1/2ke as (3.1 ± 1.4) h, Cl as (0.033 ± 0.010) L·h-1,AUC0-14 as (705 ± 247) μLg·h·L-1,and AUC0-∝ as (920 ± 283) μg·h·L-1. CONCLUSION: The pharmacokinetic parameters by oral administration ziprasidone 20 rag in 9 healthy male volunteers are similar to report of literature.