Pharmacokinetics of Single Dose Intramuscularly Injected Ziprasidone Mesylate in Healthy Volunteers

OBJECTIVE:To study the pharmacokinetics of a single dose of intramuscularly injected ziprasidone mesylate in healthy volunteers.METHODS:A total of10healthy volunteers were received intramuscularly single dose of ziprasidone me-sylate20mg,venous blood samples were taken at different time after intramuscular injection,the concentrations of ziprasidone in serum were determined by HPLC,and the pharmacokinetic parameters were calculated with3p97program.RESULTS:The concentration-time curves of ziprasidone fitted to two-compartment model.The pharmacokinetic parameters were stated as follows,C max was(866.32±482.88)ng/ml;t max was(0.57±0.23)h,t 1/2ke was(2.17±1.04)h,CL was(17.0±9.00)ml/h,AUC 0～12 was(1467.94±644.80)(ng·h)/ml and ACU 0～∝ was(1603.48±722.47)(ng·h)/ml.CONCLUSIONS:The pharmacoki-netics parameters in10healthy volunteers after intramuscular injection of20mg ziprasidone mesylate are in line with that re-ported in the literature.