Pharmacokinetics Study of Ziprasidone Tablets in Chinese Healthy Volunteers

OBJECTIVE:To study the pharmacokinetics of Ziprasidone tablets in healthy volunteers. METHODS:20 healthy subjects received a single oral dose of ziprasidone tablets 40 mg. Blood samples of ulnar vein were taken before medication and 0,0.5,1,2,3,4,5,6,8,12,16,24,36,48 h after medication. The plasma concentrations of ziprasidone were determined by HPLC. Pharmacokinetic parameters were analyzed by DAS 2.0 software. RESULTS:Plasma concentration-time curves of ziprasidone conformed to one-compartment model. Main pharmacokinetics parameters of ziprasidone were as follow:cmax was (167.74±58.43) ng/mL,tmax was (3.72±1.86) h,t1/2was (5.57±1.63) h,AUC0-48 h was (1 285±252.59) ng· h/ml,AUC0-∞was (1 396.75±276.54) ng· h/ml,respectively. CONCLUSIONS:The pharmacokinetics of ziprasidone in human volunteers conforms to one-compartment model. The study can provide reference for the clinical application of ziprasidone.