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2006•Strait Pharmaceutical JournalRequires access

A Randomized Clinical Study of Cefpodoxime Proxetil vs Cefixime in Treatment of Acute Bacterial Infections

Guo Yang-qing

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Abstract

OBJECTIVE To evaluate the safely and efficacy of cefpodoxime proxetil vs cefixime in the treatment of acute bacterial infections.METHODS A randomized clinical study was conducted for comparing domestic cefpodoxime proxetil with cefixime.115 patinents were enrolled in the study,60 in domestic cefpodoxime proxetil group,55 in control group.Cefpodoxime proxetil was used as 100mg po.Twice a day and cefixime was used 200mg po.twice a day for 7～14 days.RESULTS In trial and controlled group the total cure rate were 73% 69%,respectively;the total efficacy rate are 92% and 91%,respectively;the total bacterial clearance rates of both groups were 98% and 94% respectively.Adverse reactions were observed for 7% and 6% of patients in the two groups.There were no statistically significant difference between teh results of both groups(P0.05).CONCLUSIONS cefpodoxime proxetil are effective and safe in the treatment of acute bacterial infections.

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OBJECTIVE To evaluate the safely and efficacy of cefpodoxime proxetil vs cefixime in the treatment of acute bacterial infections.METHODS A randomized clinical study was conducted for comparing domestic cefpodoxime proxetil with cefixime.115 patinents were enrolled in the study,60 in domestic cefpodoxime proxetil group,55 in control group.Cefpodoxime proxetil was used as 100mg po.Twice a day and cefixime was used 200mg po.twice a day for 7～14 days.RESULTS In trial and controlled group the total cure rate were 73% 69%,respectively;the total efficacy rate are 92% and 91%,respectively;the total bacterial clearance rates of both groups were 98% and 94% respectively.Adverse reactions were observed for 7% and 6% of patients in the two groups.There were no statistically significant difference between teh results of both groups(P0.05).CONCLUSIONS cefpodoxime proxetil are effective and safe in the treatment of acute bacterial infections.

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Available abstract

OBJECTIVE To evaluate the safely and efficacy of cefpodoxime proxetil vs cefixime in the treatment of acute bacterial infections.METHODS A randomized clinical study was conducted for comparing domestic cefpodoxime proxetil with cefixime.115 patinents were enrolled in the study,60 in domestic cefpodoxime proxetil group,55 in control group.Cefpodoxime proxetil was used as 100mg po.Twice a day and cefixime was used 200mg po.twice a day for 7～14 days.RESULTS In trial and controlled group the total cure rate were 73% 69%,respectively;the total efficacy rate are 92% and 91%,respectively;the total bacterial clearance rates of both groups were 98% and 94% respectively.Adverse reactions were observed for 7% and 6% of patients in the two groups.There were no statistically significant difference between teh results of both groups(P0.05).CONCLUSIONS cefpodoxime proxetil are effective and safe in the treatment of acute bacterial infections.

Key concepts: Cefpodoxime, Cefixime, Medicine, Internal medicine, Clinical efficacy, Ceftizoxime, Gastroenterology, Cephalosporin

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