Relationship between changes of the levels of plasma oxidized low density lipoprotein and paraoxonase 1 activity in patients with coronary heart disease

Objective To investigate the relationship between changes of the levels of plasma oxidized low density lipoprotein (oxLDL) and paraoxonase 1 (PON1) activity in patient with coronary heart disease (CHD) and to probe the possible role of PON1 in CHD. Methods Serum PON1 activity was measured by spectro photometry and level of plasma oxLDL was determined with enzyme linked immunosorbent assay (ELISA) in 99 patients with coronary heart disease,including 35 cases of stable angina (SAP group),30 cases of unstable angina (UAP group), 34 cases of acute myocardial infarction (AMI group) and 42 normal control subjects. At the same time,analysis of linear correlation was performed to estimate the relationship between the activity of PON1 and the level of oxLDL.Results Serum PON1 activity in CHD was significantly lower than that in the controls and plasma oxLDL level was significantly higher in CHD than in the controls. In CHD patients, serum PON1 activity in SAP, UAP and AMI groups was significantly decreased, and plasma oxLDL levels were increased as compared with the control group.The analysis of linear correlation showed that PON1 was negatively correlated with oxLDL. Conclusion In patients with CHD, serum paraoxonase 1 activity was decreased and plasma oxLDL levels were increased, such changes may be related to the development and progress of CHD.