THE CHANGES AND THE CLINICAL SIGNIFICANCE OF OXIDATIVE LOW DENSITY LIPOPROTEIN AND SOLUBLE INTERCELLULAR ADHESION MOLECULE 1 IN PATIENTS WITH CORONARY HEART DISEASE

Objective To explore the changes and clinical significance of serum oxidative low density lipoprotein(OXLDL) and soluble intercellular adhesion molecule-1(sICAM-1) levels in patients with coronary heart disease(CHD).MethodsBy using enzyme-linked immunosorbent assay(ELISA),OXLDL and sICAM-1 were measured in patients with acute myocardial infarction(AMI),with unstable angina pectoris(UAP) and with stable angina pectoris(SAP),20 patients in each group and 20 controls.Results The serum levels of OXLDL,sICAM-1 in AMI patients were much higher than that of UAP,SAP and the controls(F=37.85,27.37;q=6.14-14.09;P0.01),the levels of OXLDL and sICAM-1 were much higher in UAP than that of SAP and the controls(q=4.74-7.67,P0.01),the difference of levels of OXLDL and sICAM-1 between SAP and the controls was significant(q=2.93,2.90;P0.05).The levels of OXLDL and sICAM-1 revealed a positive correlation between different-type CHD(r=0.770-0.862,P0.01).The areas of levels of OXLDL and sICAM-1 under the ROC curve(AUCROC) were all greater than 0.9 with the sensitivity and specificity of 0.90,0.90 and 0.90,0.95 in AMI,and 0.85,0.90 and 0.80,0.85 in UAP,respectively.Conclusion The changes of OXLDL and sICAM-1 possess a great value and higher accuracy in the diagnosis of AMI and UAP and both parameters were positively correlated.The rising degree of OXLDL and sICAM-1 may be used as one of the indexes for estimating the severity of inflammation and of the disease.