STUDY OF THE ONSET TIME AND THE CHANGE IN TREATMENT FOR CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA WITH INTERLEUKIN-11 AND HORMONE

[Objective]To investigate the onset time and platelet changes in the treatment of chronic idiopathic thrombocytopenic purpura with IL-11 combined with dexamethasone.[Methods]90 chronic idiopathic thrombocytopenic purpura patients as research subjects in our hospital from January 2006-January 2010 were randomly divided into three groups,of which A group carried out IL-11 treatment,B group treated with dexamethasone,C group were combined hormone Interleukin-11 treated,observed and compared the onset time and platelet changes in three groups.[Results]After treatment,the total effective rate in C group was significantly higher than that in group A,B,and the time that C group reached the normal level of platelets was significantly shorter with the A group,B group(P all ﹤0.05).After beingtreated,platelets were significantly higher in three groups than before treatment,C group with more obvious increase,showed statistically significant differences between groups(P all ﹤0.05).The side effects were insomnia,hypertension,hyperglycemia,secondary infection,moon face,central obesity,and gastrointestinal bleeding.The incidence of side effects in C group was significantly lower than A,B groups,it showed statistically significant difference(P both ﹤0.05),but between A,B groups,it showed no significance(P﹥0.05).[Conclusion]Interleukin-11 combined hormone treatment for chronic idiopathic thrombocytopenic purpura is with faster onset time and less side reactions,significantly improves platelet function,which is worthy of clinical application.