Expression and Clinical Significance of Pokemon and NF-κBp65 in Breast Cancer

Objective To explore the expression and the interaction of Pokemon and NF-κBp65 in the course of carcinogenesis and metastasis of breast cancer。Methods The expression of Pokemon and NF-κBp65 was examined in 50 cases of primary breast cancer,20 cases of adjacent noncancerous breast tissue by immunohistochemical assay.Results The rates of strong positive nuclear Pokemon expression in breast cancer and adjacent noncancerous breast tissue were 71.2% and 40%,respectively.The difference was statistically significant.The positive rates of nuclear NF-κBp65 expression in breast cancer and adjacent noncancerous breast tissue were 57.7% and 35%,respectively.The difference was not statistically significant.The positive expression of Pokemon in breast cancer was strongly related to lymph node metastasis(P0.05).Whereas the expression of NF-κBp65 in breast cancer was strongly related to histological grade(P0.05).There was a positive corelation between the strong positive nuclear Pokemon expression and the positive nuclear NF-κBp65 expression(P0.05).Conclusion Pokemon and NF-κBp65 participated in the pathogenesis and metastasis of breast cancer,Pokemon may be an important regulator of NF-κBp65.