Clinical Significance of Thrombopoietin and Helicobacter Pylori in Patients with Idiopathic Thrombocytopenic Purpura

Objective To investigate the clinical significance of thrombopoietin(TPO) and Helicobacter pylori(HP) in patients with idiopathic thrombocytopenic purpura(ITP).Methods 60 patients with newly diagnosed ITP,their serum TPO concentration were detected by double-antibody sandwich enzyme-linked immunosorbent assay(ELISA);and the bone Marrow megakaryocytes were recorded;HP was detected by 14C urea breath test.The control group of 40 cases was also detected by above methods.Results the TPO of ineffective group with ITP were significantly higher than that of the effective group and the control group(P0.05);The megakaryocytes of ineffective group were significantly lower than that of the effective group(P0.01).HP was found in 30 of 60 patients,17 was found of 40 in the control group(P0.05).But HP was found in 10 of 13 patients of ineffective group,that was significantly higher than control group(P0.05),the platelet counts of 6 significantly increased in 10 patients after anti-HP treatment.Conclusion High levels of serum TPO and lower megakaryocyte counts may indicate that the treatment of ITP is more difficult;HP may be involved in its pathogenesis,anti-HP treatment is effective in part of ITP.