An Observation on Relationship of Thrombopoietin and Beta2-microglobulin with the Curative Results of Idiopathic Thrombocytopenic Purpura

Objective:To investigate the relationship of serum thrombopoietin(TPO),and beta-2mi-croglobulin(β2-M) with the curative results of idiopathic thrombocytopenic purpura(ITP).Methods:Thirty patients with newly diagnosed ITP were divided into effective group(group E,n=23) and ineffective group(group I,n=7),according to their curative results.The serum TPO concentrations of all of the patients and 20 healthy people(as control,group C) were detected by using double-antibody sandwich enzyme-linked immunosorbent assay(ELISA),and the serum β2-M concentrations were detected by using radio-immunoassay(RIA).Bone marrow megakaryocytes were counted before the treatment of ITP.Results:The megakaryocyte counts of patients in group I were significantly lower than that of patients in group E(P0.01);The TPO and β2-M levels of patients in group I were significantly higher than those of patients in group E and healthy people in group C(P0.05),and kept significantly higher than those of group C after a period of treatment(P0.05).The TPO and β2-M levels of the patients in two groups did not change significantly before and after the treatment(P0.05).Conclusions:High levels of serum TPO and β2-M in ITP patients may be a sign indicating the difficulty in treatment,and there might be some differences in pathogenesis between effectively cured and difficultly-treat ITP patients.