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2007•Chinese Journal of Birth Health & HeredityRequires access

Detection of polymorphisms of methylenetetrahydrofolate reductase of Han population in Henan

Bo Song

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Abstract

Objective:To identify the distribution feature of MTHFR C677T genes in Han population in Henan province.Mehtords:The polymorphisms of MTHFR C677T gene were detected using PCR-RFLP.Results:There were three kinds of genetypes:homozygous mutation TT-type,heterozygous mutation CT-type,and wild-type CC.The frequencies of the three genetypes were as follows:TT-type 32.8%,CT-type 34.6%,CC-type 32.6%.Conclution:MTHFR C677T,gene polymorphisms are common in Henan Han population.There were possibly exists ethic or geographic diference in these three polymorphisms.There may be diversity among diffenent races and regions.

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What this paper is about

Objective:To identify the distribution feature of MTHFR C677T genes in Han population in Henan province.Mehtords:The polymorphisms of MTHFR C677T gene were detected using PCR-RFLP.Results:There were three kinds of genetypes:homozygous mutation TT-type,heterozygous mutation CT-type,and wild-type CC.The frequencies of the three genetypes were as follows:TT-type 32.8%,CT-type 34.6%,CC-type 32.6%.Conclution:MTHFR C677T,gene polymorphisms are common in Henan Han population.There were possibly exists ethic or geographic diference in these three polymorphisms.There may be diversity among diffenent races and regions.

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Available abstract

Objective:To identify the distribution feature of MTHFR C677T genes in Han population in Henan province.Mehtords:The polymorphisms of MTHFR C677T gene were detected using PCR-RFLP.Results:There were three kinds of genetypes:homozygous mutation TT-type,heterozygous mutation CT-type,and wild-type CC.The frequencies of the three genetypes were as follows:TT-type 32.8%,CT-type 34.6%,CC-type 32.6%.Conclution:MTHFR C677T,gene polymorphisms are common in Henan Han population.There were possibly exists ethic or geographic diference in these three polymorphisms.There may be diversity among diffenent races and regions.

Key concepts: Methylenetetrahydrofolate reductase, Genetics, Restriction fragment length polymorphism, Polymorphism (computer science), Biology, Population, Gene, Genotype

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Detection of polymorphisms of methylenetetrahydrofolate reductase of Han population in Henan — Research Paper | ScholarLens