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2010•Chinese Journal of Birth Health & HeredityRequires access

Detection of genetic polymorphisms of METHFR of Han population in Huaihua

Jiang Hai-o

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Abstract

Objective:To investigate the distribution feature of MTHFR C677T genes in Han population in Huaihua.Mehtords:RFLP was used for genetyping of MTHFR C677T in 120 healthy subjects.Results:There were three kinds of genetypes:homozygousmutation TT-type,heterozygousmutation CT-type,and wild-type CC,and their frequencies were 12.5%,34.2% and 53.3%,respectively.Conclution:There is a significant difference among different races and regions in gene polymorphisms distribution of the MTHFR C677T.

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What this paper is about

Objective:To investigate the distribution feature of MTHFR C677T genes in Han population in Huaihua.Mehtords:RFLP was used for genetyping of MTHFR C677T in 120 healthy subjects.Results:There were three kinds of genetypes:homozygousmutation TT-type,heterozygousmutation CT-type,and wild-type CC,and their frequencies were 12.5%,34.2% and 53.3%,respectively.Conclution:There is a significant difference among different races and regions in gene polymorphisms distribution of the MTHFR C677T.

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Available abstract

Objective:To investigate the distribution feature of MTHFR C677T genes in Han population in Huaihua.Mehtords:RFLP was used for genetyping of MTHFR C677T in 120 healthy subjects.Results:There were three kinds of genetypes:homozygousmutation TT-type,heterozygousmutation CT-type,and wild-type CC,and their frequencies were 12.5%,34.2% and 53.3%,respectively.Conclution:There is a significant difference among different races and regions in gene polymorphisms distribution of the MTHFR C677T.

Key concepts: Methylenetetrahydrofolate reductase, Genetics, Polymorphism (computer science), Restriction fragment length polymorphism, Population, Biology, Significant difference, Genotype

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