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Formulation optimization of Wushen Dispersible Tablets by central composite design-response surface method

Xiao Ting-tin

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Abstract

Objective To optimize the formulation of Wushen Dispersible Tablets by central composite design-response surface method(CCD-RSM).Methods The amounts of MCC,cCMC-Na,and PVPP XL were regarded as independent variables,and disintegration time and dissolution rate were regarded as dependent variables.The optimal formulation was predicted by response surface method and was verified as well.Results The optimal molding technology was as follows:MCC was 35%,cCMC-Na was 12%,and PVPP XL was 10%.The predicted value was very close to the measured value.Conclusion The mathematical model of Wushen Dispersible Tablets formulation could be achieved by CCD-RSM with the prefect prediction.

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What this paper is about

Objective To optimize the formulation of Wushen Dispersible Tablets by central composite design-response surface method(CCD-RSM).Methods The amounts of MCC,cCMC-Na,and PVPP XL were regarded as independent variables,and disintegration time and dissolution rate were regarded as dependent variables.The optimal formulation was predicted by response surface method and was verified as well.Results The optimal molding technology was as follows:MCC was 35%,cCMC-Na was 12%,and PVPP XL was 10%.The predicted value was very close to the measured value.Conclusion The mathematical model of Wushen Dispersible Tablets formulation could be achieved by CCD-RSM with the prefect prediction.

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Available abstract

Objective To optimize the formulation of Wushen Dispersible Tablets by central composite design-response surface method(CCD-RSM).Methods The amounts of MCC,cCMC-Na,and PVPP XL were regarded as independent variables,and disintegration time and dissolution rate were regarded as dependent variables.The optimal formulation was predicted by response surface method and was verified as well.Results The optimal molding technology was as follows:MCC was 35%,cCMC-Na was 12%,and PVPP XL was 10%.The predicted value was very close to the measured value.Conclusion The mathematical model of Wushen Dispersible Tablets formulation could be achieved by CCD-RSM with the prefect prediction.

Key concepts: Response surface methodology, Central composite design, Composite number, Dissolution, Materials science, Molding (decorative), Chromatography, Mathematics

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