Optimization of the preparation of Lamiophlomis rotata dispersible tablets using central composite design

OBJECTIVE To optimize the preparation of dispersible tablets using central composite design. METHODS Dispersible tablets were prepared by direct compression method. The effects of dissolution time( (go of luteoloside), disintegration time, suspending coefficient and overall desirability value on the PVPP,pregelatinized starch and colloidal silicium dioxide were investigated.The optimal formulation was established by the central composite design and response surface method. A second-order polynomial eolation was fitted to the data and resultant model was used to predict the response in the optimal region.RESULT All the investigated response variables were found to be highly dependent on the formulation variables. Lamiophlomis rotata dispersible tablets were prepared by selecting 12% PVPP as disintegation agent, 14% Pregelatinized Starch as sweller,3% colloidal silicium dioxide as lubricant and clidant,and 45% MCC as filler. Under the optimized condition, the values of dissolution time ( t80 of luteoloside), disintegration time and suspending coefficient were 1.68 min, 20.6 s and 0.068 9.CONCLUSION Fast dispersible tablets with acceptable hardness and desirable taste could be prepared using central composite design.