Optimization of Jinghuo Tablets Formulation by Central Composite Design-response Surface Methodology

The formulation of Jinghuo dispersible tablets was optimized by single factor and central composite design-response surface methodology,optimized results were validated.The optimizing parameters were obtained as follows:1.1 times MCC,0.35 times CMS-Na,0.19 times L-HPC,pressure 4 kN,distilled water as the wetting agent.Model developed by single factor and central composite design-response surface methodology can be used for the optimization of Jinghuo dispersible tablets formulation.Established model deliver predictive accuracy.