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2012•The Chinese Journal of Clinical PharmacologyRequires access

A comparative study of olanzapine and quetiapine in the treatment of negative symptoms of schizophrenia

LI Ya-zhong

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Abstract

Objective To compare the efficacy and safety of olanzapine in the treatment of negative symptoms of schizophrenia.MethodsEighty patients diagnosed negative symptoms of schizophrenia by DSM-Ⅳ were randomly allocated to two groups and treated with olanzapine or quetiapine for 8 weeks,respectively.The efficacy and side effects were evaluated by PANSS,CGI and TESS.ResultsThe significant efficacy rates for the olanzapine and quetiapine groups were 87.2% and 81.1%.There was no significant difference in efficacy between the two groups.The rates of side effects were similar in two groups,including lethargy and weight gain.ConclusionThe results suggest that olanzapine is as effective and safe as quetiapine for patients with negative symptoms of schizophrenia.

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What this paper is about

Objective To compare the efficacy and safety of olanzapine in the treatment of negative symptoms of schizophrenia.MethodsEighty patients diagnosed negative symptoms of schizophrenia by DSM-Ⅳ were randomly allocated to two groups and treated with olanzapine or quetiapine for 8 weeks,respectively.The efficacy and side effects were evaluated by PANSS,CGI and TESS.ResultsThe significant efficacy rates for the olanzapine and quetiapine groups were 87.2% and 81.1%.There was no significant difference in efficacy between the two groups.The rates of side effects were similar in two groups,including lethargy and weight gain.ConclusionThe results suggest that olanzapine is as effective and safe as quetiapine for patients with negative symptoms of schizophrenia.

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Available abstract

Objective To compare the efficacy and safety of olanzapine in the treatment of negative symptoms of schizophrenia.MethodsEighty patients diagnosed negative symptoms of schizophrenia by DSM-Ⅳ were randomly allocated to two groups and treated with olanzapine or quetiapine for 8 weeks,respectively.The efficacy and side effects were evaluated by PANSS,CGI and TESS.ResultsThe significant efficacy rates for the olanzapine and quetiapine groups were 87.2% and 81.1%.There was no significant difference in efficacy between the two groups.The rates of side effects were similar in two groups,including lethargy and weight gain.ConclusionThe results suggest that olanzapine is as effective and safe as quetiapine for patients with negative symptoms of schizophrenia.

Key concepts: Olanzapine, Quetiapine, Schizophrenia (object-oriented programming), Negative symptom, Lethargy, Medicine, Significant difference, Psychiatry

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