Comparative study between the effect of olanzapine and quetiapine in first-episode schizophrenia

Objective:To compare the efficacy and safety of olanzapine and quetiapine in the treatment of first-episode schizophrenia. Method:80 patients with first-episode schizophrenia(according to Chinese classification of mental disorders,third edition) were divided into two groups who treated with olanzapine or quetiapine respectively for 6 weeks.The positive and negative syndrome scale(PANSS) and treatment emergent side effect scale(TESS) were used to evaluate efficacy and adverse effect before and after treatment respectively.Results:The scores of positive syndrome of PANSS in olanzapine group was significantly lower than quetiapine group at 6 week after trentment.There was no significant differences in the scores of negative syndrome scale,general and total scale of PANSS between two groups.The most adverse effects of olanzapane were weight gain,liver dysfunction and extrapyramidal side effects.The most adverse effects of quetiapine were drowsiness and dizzy. Conclusion:The efficacy on positive syndrome of olanzapine is better than that of quetiapine,and they both have fewer side effects.