Expression of PTEN Encoding Product and its Significance in Gastric Cancer and Precancerous Lesion

Objective: Our aim was to observe the expression of PTEN protein in gastric cancer and precancerous lesion, thus to investigate the relationship between PTEN expression and the pathogenesis of gastric cancer. Methods: We detected the PTEN protein expression with SP immunohistochemistry method in cases of gastric cancer and precancerous lesion. Results: The expression rate of PTEN product in normal gastric mucosa was 100%. In cases of chronic superficial gastritis, atrophic gastritis without intestinal metaplasia, atrophic gastritis with intestinal metaplasia, moderate dysplasia, severe dysplasia, gastric cancer of early and advanced stage, the expression of PTEN rate was 98.3%, 91.6%, 78.3%, 75.0%, 63.3%, 61.7%, 43.3%, respectively. Among the 120 patients with gastric cancer, 76 were intestinal type, the expression rate of PTEN protein was 60.5%, 44 were diffused type, the expression rate was 38.6%. Conclusion: The expression of PTEN protein was down regulated in the process of gastric cancer. The PTEN protein can be used as a maker to evaluate the biological behavior of gastric cancer.