2005•Unpublished venueRequires access
Expression of PTEN enconding product in gastric carcinoma and its significance
Guanghong Guo
Open publisher page 0 citations
Abstract
Objective To illustrate the significance of expression of phosphatase and tensin homolog deleted on chromosome ten(PTEN) enconding product in carcinoma of the stomach,and to evaluate its relationship with the occurrence and clinicopathological features of the disease.Methods Formalin-fixed and paraffin-embedded tissues from 60 cases of gastric carcinoma,17 cases of gastric dysplasia and 15 cases normal gastric mucosa were evaluated for the expression of PTEN by SP immunohistochemistry.Results The positive rates of PTEN protein were 100%,70.59% and 46.67% in normal gastric mucosa,dysplasia and gastric carcinoma,the difference of PTEN gene expression was significant(P0.05);however the difference of PTEN gene expression was't significant between gastric dysplasia and early stage gastric carcinoma;PTEN was less expressed in advanced gastric dysplasia and early stage gastric carcinoma;PTEN was less expressed in advanced gastric carcinoma than in early stage gastric carcinoma;PTEN was less expressed in advanced gastric carcinoma than in early ones(36.59%,68.42%,P0.05);The positive rates of PTEN protein decreased with lymph node metastasis,poor differentiation,deep invasion,apparatus metastasis and clinical staging(P0.05).Conclusion PTEN may be an objective marker for pathologically biologically behavior of gastric carcinoma.