2001•Hebei yixueRequires access
Expression of P21 and P53 in 145 human gastric carcinoma
Weiqing Huang
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Abstract
Objective: To study the expression of cancer gene product and anti-cancer gene product in the same gastric carcinoma.Methods:Immunohistochemical staining was used to determine the expression of P21 and P53 in 10 normal stomach mucous membrane.10 atrophic gastritis. 10 intestinal metaplasia and 145 gastric carcinoma. Results: No P21 and P53 were expressed in the 10 normal stomach mucous membrane. 10 atrophic gastritis. 10 intestinal metaplasia samples. The positive incidence of P21 and P53 expression in the gastric carcinoma were 55.2% and 51 .2% respectively. The dexpression of P21 and P53 correlated to the degree of gastric carcinoma differtiation .P53 was located in cell nuclei and P21 located on the cell membrane or cell starch in gastric carcinoma.Conclusion:These results suggest that P21 and P53 may be used to determine the prognosis of gastric carcinoma patients.