2001•J0urnal of Nanjing Military Medical CollegeRequires access
Expression of P16 protein in precancerosis and gastric carcinoma
Zhao Zhi-quan
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Abstract
Objective: To investigate the expression of P16 protein in premalignant lesions and gastric carcinoma, including dysplastic gastric mucosa and intestinal metaplasia in gastric mucosa. Methods:The expression of P16 proteins were measured by SP immunohistochemical method in normal gastric mucosa (10 specimens), dysplastic gastric mucosa (15 specimens), intestinal metaplasia in gastric mucosa (15 specimens), gastric carcinomas (30 specimens). Results:The positive expression of P16 protein was 90% in normal gastric mucosa, 86. 67% in dysplastic gastric mucosa, 86.67% in intestinal metaplasia, 36.67% in gastric carcinoma. There were significant differences between gastic carcinoma group and the normal control group or the precancerous group (P 0. 01). Conclusion: P16 protein is associated with the occurrence of gastric carcinoma.