2004•Journal of Shenyang Medical CollegeRequires access
The Study of Expression of p53 in Gastric Carcinoma and Precarcinomatous Tissue
Zhang Zhong
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Abstract
Objective: To study the change of the expression of p53 protein in the progression of gastric carcinoma. Methods:The expression of p53 protein was analyzed through immunohistochemical staining of 206 gastric mucus biopsy including normal gastric mucus, chronic superficial gastritis, colonial epithelium metaphasia, atypical proliferation and gastric carcinoma. Results:There is no p53 protein expression in normal gastric mucus and chronic superficial gastritis. In colonial epithelium metaphasia, p53 protein expression is higher than that in normal gastric mucus and chronic superficial gastritis. p53 protein expression positive rate in atypical proliferation is higher than that in colonial epithelium metaphasia, but lower than that in gastric carcinoma tissue. Conclusion; p53 gene mutation is the key point in gastric carcinoma progression.