Effects of ileal transposition on blood glucose in type 2 diabetic rats

Objective To investigate the hypoglycemic effect of ileal transposition(IT) on streptozotocic(STZ) treated diabetic rats and its mechanisms.Methods SD diabetic rats treated by STZ were randomly allocated into 3 groups:IT(group IT),S-IT(group S-IT),C(group C).Plasma glucose concentrations,Glucagonlike-peptide-1(GLP-1) were measured respectively at fasting and postprandial condition before surgery and 1、2、4 and 8 weeks after surgery in all rats.Results The fasting and postprandial blood glucose of IT group rats decreased to(6.73±1.78)、(12.46±2.54) mmol/L from(18.96±1.13)、(31.82±2.33) mmol/L after surgery 8 weeks(P0.01),respectively.The fasting and postprandial plasma GLP1 of IT group raised respectively to(24.23±1.75)、(89.74±2.96) pmol/L from (10.16±1.65)、(21.50±1.68) pmol/L after surgery 8 weeks(P0.01),much more significant at the post oral glucose condition.No differences were recorded between the IT group and S-IT group rats in terms of weight.Conclusion Ileal transposition can effectively improve blood glucose of non-obese type 2 diabetic rats,proposed that the stimulation of the terminal ileum by the early arrival of food,play a vital role in causing raised secretion of GLP-1.