2013•Zhonghua shiyan waike zazhiRequires access
Effect of gastric bypass on glucose reduction and glucagon-like peptide-1 secretion of rats with type 2 diabetes
Xing Bao, Min Du, Jing-yu Dai, Jie Zhang
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Abstract
Objective To investigate the effect of gastric bypass (GBP) on rats with type 2 diabetes induced by streptozotocin (STZ) injection and the action mechanisms involved.Methods Twenty rats were divided into 4 groups:operation group (group O,n =18),sham operation group (group S,n =15),food control group (group F,n =15) and control group (group C,n =15).Weight,fasting blood glucose (FBG),fasting plasma insulin (FPI) and glucagon-like peptide-1 (GLP-1) were measured 1,2,4 and 8 weeks after operation.Results (1) FBG in O group 8 weeks after operation was reduced to (8.2 ±2.4) mmol/L (P ＜ 0.05) ; (2) FPI in O group was increased after operation and reached (72.5 ±7.4) mU/L at week 8 was compared with that before operation [(29.1 ± 5.1) mU/L] ; (3) GLP-1 in O Group at 8th week after operation was increased to (23.26 ± 2.19) pmoL/L(P ＜0.05).Conclusion GBP was an effective therapy to control blood glucose in type 2 diabetic rats and lead to high secretion of GLP-1.There is no significant relation between decreased blood glucose in type 2 diabetic rats with restricted diet and weight loss after GBP.
Key words:
Gastric bypass; Type 2 diabetic; Glucagon-like peptide-1