The Study of Serum Bilirubin Inpatients with Cerebral Infarction

Objective:To study the clinical implication between serum bilirubin with cerebral infarction(CI).Methods:A total of 203 CI patients were divided into massive CI group(73 patients)and non-massive group(130 patients).Serum total bilirubin,direct bilirubin,and indirect bilirubin were measured in 24 hour and 2 weeks after infarction onset.Another 100 healthy subjects served as the control.Results:In 24 hour,both CI groups had high serum bilirubin levels than the control did;the massive CI group had the highest compared to the non-massive and the control groups(P0.01).In 2 weeks,both CI groups had significantly lower serum bilirubin levels than the control did(P0.01),with greater reduction in total and indirect bilirubin.Conclusions:The remarkable increase of serum bilirubin in 24 hour after infarction which may be an early sign for massive CI is important to help evaluate the diagnosis and prognosis of CI,especially when the diagnosis has not been confirmed by CT or MRI.Hypo-bilirubin may be an independent risk factor for CI.