High-risk HPV virus sub-type and liquid-based cytology analysis in screening of early cervical lesions

Objective:To compare the effect of high-risk HPV virus typing(HR-HPV)and liquid based cytology(TCT)in early screening of cervical lesions.Methods:Combined with pathological diagnosis,screening results from 1 384cervical cancer patients in our hospital were retrospectively analyzed.The sensitivity of HR-HPV,TCT and combination detection was compared.Results:Out of 1 384cases,HRHPV positive rate of inflammation and normal patients was 3.6%,HR-HPV positive rate was 57.0%in patients with lesions more severe than CIN1,the difference was significant(P0.05).There was significant difference in detection rate among HR-HPV-negative rate,single positive rate and combination positive rate during detection of inflammation,CIN1lesions and lesions more severe than CIN1(χ 2=694.22,P0.05).There were 35cases misdiagnosed by TCT,including 8cases with HR-HPV positive;while there were 26cases missed by TCT,including 15cases of with HR-HPV positive.The sensitivity of TCT was 94.3%,HR-HPV was 57.0%,and combination detection was 98.0%.Conclusion:HR-HPV screening provide supplement for TCT,the combination detection can increase sensitivity of screening.