Application of High-risk HPV Combined with Liquid-based Cytology Technology in the Diagnosis of Cervical Lesions

Objective To investigate the application of high-risk HPV genotyping assay combined with liquid-based cytology for cervical lesions. Methods Liquid-based cytology samples of 204 cases of cervical cancer were detected by high-risk HPV genotyping assay,and were compared with cervical biopsy results. Results 138 patients were TCT-positive combined with HPV infection,LSIL showed that HPV-positive was 40 cases( 29. 0%),HSIL showed that HPV-positive was 10 cases( 7. 2%), ASCUS showed that HPV-positive was 80 cases( 58. 0%),SCC showed that HPV-positive was 8 cases( 5. 8%). High-risk HPV was 42 cases,and positive rate was 30. 4%. Samples of different types of high-risk HPV infection had significant difference( P 0. 05). When TCT and HPV were both(-),there had no high grade lesion. When HPV-positive and TCT abnormal both occurred,detection rate of ≥ CIN Ⅰ was 34. 8%. When TCT was abnormal HPV(-),the detection rate was 47. 8%. Conclusion High-risk HPV genotyping assay combined with liquid-based cervical cytology is a valuable method for early screening of cervical cancer,the result is more reliable than single inspection.