Application of dynamic light scattering on the evaluation of the different docetaxel liposome preparations and the compatible stability

Objectives To assess docetaxel liposome preparations and compatible stability using dynamic light scattering technology.Methods Docetaxel liposome preparations A-E containing different content of membrane stabilizerⅠand DSPE-mPEG2 000 were prepared,then the corresponding intensity-weighted particle size distributions(PSDI) were assessed using Gaussian analysis and Nicomp distribution analysis.Furthermore,the particle size stability of docetaxel liposome preparation E diluted by sodium chloride solution and glucose solution respectively were evaluated.Results Docetaxel liposome preparation E containing 7.0 g L-1membrane stabilizerⅠand 3.5 g L-1DSPE-mPEG2 000 was the best one with a good compatible stability in 8 h.Conclusions Gaussian analysis and Nicomp distribution analysis can effectively direct the evaluation of docetaxel liposome preparations and the stability.