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2008•Chinese Journal of Clinical Oncology and RehabilitationRequires access

Relation between expression of C-erbB-2,p53 genes and estrogen,progesterone receptors in breast carcinoma of patients under 35 years of age

Dongxian Zhou

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Abstract

Objective To investigate the relation between the expression of C-erbB-2,p53 and estrogen receptor(ER),progesterone receptor(PR) of breast carcinoma in patients under 35 years of age.Methods The expression of C-erbB-2,p53,ER and PR was detected by immunohistochemical technique in 100 cases of breast carcinoma under 35 years of age.Results The poistive expression rates of C-erbB-2,p53,ER,PR were 78.0%,67.6%,54.0%,54.0%,respectively.There was no correlation between the poistive expression of C-erbB-2,p53 with clinical stages,tumor size and lymphatic metastasis.Conclusion The expression rates of C-erbB-2 and p53 in breast carcinoma of patients under 35 years of age are high.It may increase metastasis potential and invasion possibility.

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What this paper is about

Objective To investigate the relation between the expression of C-erbB-2,p53 and estrogen receptor(ER),progesterone receptor(PR) of breast carcinoma in patients under 35 years of age.Methods The expression of C-erbB-2,p53,ER and PR was detected by immunohistochemical technique in 100 cases of breast carcinoma under 35 years of age.Results The poistive expression rates of C-erbB-2,p53,ER,PR were 78.0%,67.6%,54.0%,54.0%,respectively.There was no correlation between the poistive expression of C-erbB-2,p53 with clinical stages,tumor size and lymphatic metastasis.Conclusion The expression rates of C-erbB-2 and p53 in breast carcinoma of patients under 35 years of age are high.It may increase metastasis potential and invasion possibility.

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Available abstract

Objective To investigate the relation between the expression of C-erbB-2,p53 and estrogen receptor(ER),progesterone receptor(PR) of breast carcinoma in patients under 35 years of age.Methods The expression of C-erbB-2,p53,ER and PR was detected by immunohistochemical technique in 100 cases of breast carcinoma under 35 years of age.Results The poistive expression rates of C-erbB-2,p53,ER,PR were 78.0%,67.6%,54.0%,54.0%,respectively.There was no correlation between the poistive expression of C-erbB-2,p53 with clinical stages,tumor size and lymphatic metastasis.Conclusion The expression rates of C-erbB-2 and p53 in breast carcinoma of patients under 35 years of age are high.It may increase metastasis potential and invasion possibility.

Key concepts: Breast carcinoma, Medicine, Estrogen receptor, Immunohistochemistry, Progesterone receptor, Estrogen, ErbB, Carcinoma

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Relation between expression of C-erbB-2,p53 genes and estrogen,progesterone receptors in breast carcinoma of patients under 35 years of age — Research Paper | ScholarLens