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2009•Zhongguo laonianxue zazhiRequires access

Change of cytokine IL-6 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

Yang Yun

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Abstract

Objective To explore the level of cytokine interleukin 6(IL-6) in the cerebrospinal fluid(CSF) of patients with Creutzfeldt-Jakob disease(CJD) and to investigate the effect of proinflammatory cytokine on the process of CJD.Methods Subjects were divided into CJD,encephalitis and control groups.The level of IL-6 in CSF was measured by ELISA.Results Compared with control group,the levels of IL-6 in CSF of CJD patients were significantly higher.Conclusions The level of proinflammatory IL-6 of CSF is increased in CJD patients,which may play an important role in the process of neural degeneration.

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What this paper is about

Objective To explore the level of cytokine interleukin 6(IL-6) in the cerebrospinal fluid(CSF) of patients with Creutzfeldt-Jakob disease(CJD) and to investigate the effect of proinflammatory cytokine on the process of CJD.Methods Subjects were divided into CJD,encephalitis and control groups.The level of IL-6 in CSF was measured by ELISA.Results Compared with control group,the levels of IL-6 in CSF of CJD patients were significantly higher.Conclusions The level of proinflammatory IL-6 of CSF is increased in CJD patients,which may play an important role in the process of neural degeneration.

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Available abstract

Objective To explore the level of cytokine interleukin 6(IL-6) in the cerebrospinal fluid(CSF) of patients with Creutzfeldt-Jakob disease(CJD) and to investigate the effect of proinflammatory cytokine on the process of CJD.Methods Subjects were divided into CJD,encephalitis and control groups.The level of IL-6 in CSF was measured by ELISA.Results Compared with control group,the levels of IL-6 in CSF of CJD patients were significantly higher.Conclusions The level of proinflammatory IL-6 of CSF is increased in CJD patients,which may play an important role in the process of neural degeneration.

Key concepts: Cerebrospinal fluid, Proinflammatory cytokine, Medicine, Cytokine, Disease, Immunology, Interleukin, Encephalitis

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