Characteristics of lipid profile in CHD patients with metabolic syndrome and the relationship between metabolic syndrome and the severity of coronary artery stenosis.

Objective To investigate the characteristics of lipid profile in coronary heart disease (CHD) patients with metabolic syndrome (MS) and the relationship between MS and the severity of coronary artery stenosis. Methods A total of 100 patients were definitely diagnosed with CHD by coronary arteriography, and their lipid profiles as well as Gensini score of coronary artery were tested. All these patients were categorized into two groups based on whether the patients were combined with MS: the MS group (n=54) and the non-MS group (n=46). The blood glucose and lipid levels were determined, the severity of coronary artery disease was evaluated according to the results of coronary angiography. Results BMI, BP, fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), apolipoprotein (Apo) B and uric acid (UA) levels were significantly higher in MS group than those in non-MS group (P0.05), but levels of high density lipoprotein cholesterol (HDL-C) were significantly lower in MS group (P0.01). Also coronary three-vessel lessions were more frequently identified and stenosis score was higher in patients of MS group. Conclusion Most parameters of lipid of the CHD patients with MS are significantly differ from those of CHD patient without MS, and MS maybe related to the severity and number s of coronary artery lesions.