Characteristics of lipid profile in CHD patients with metabolic syndrome and the relationship between metabolic syndrome and the severity of coronary artery stenosis

Objective:To investigate the characteristics of lipid profile in coronary heart disease(CHD) patients with metabolic syndrome(MS) and the relationship between MS and the severity of coronary artery stenosis.Methods:A tatol of 328 hospitalized patients with chest pain underwent coronary angiography,and among these patients,258 patients were diagnosed as CHD.All these patients were categorized into two groups by with or without metabolic syndrome.The lipid profile and Gensini score of coronary artery were tested.Results:Compared with the CHD without MS group,the patients of CHD with MS had more severe coronary artery stenosis and more lesion vessels(P0.01).The CHD with MS group had higher levels of total cholesterol(TC),triglyceride(TG),apolipoprotein(Apo) B and ApoBApoA1 ratio(P0.05~0.01),but lower levels of high density lipoprotein cholesterol(HDL-C,P0.01).However,there was no statistical significance difference in levels of low density lipoprotein cholesterol(LDL-C) and ApoA1 between these two groups(P0.05).The ROC curve analysis showed that TG had largest area under curve(AUC,0.732),followed by ApoB,LDL-CHDL-C,HDL-C and ApoBApoA1 ratio.Conclusion:Most parameters of lipid of the patients with CHD and MS are significant differ from those CHD patient without MS,and MS maybe relate to the severity and numbers of coronary artery lesions.TG,TC,HDL-C and ApoB are the good parameters in evaluating MS.