Analgesic effect of parecoxib sodium in patients with myasthenia gravis after thymectomy

Objective To evaluate the analgesic effect of parecoxib sodium in patients with myasthenia gravis after thymectomy. Methods One hundred and fifty-seven patients with myasthenia gravis after thymectomy were divided into tramadol group( 51 patients were given intramuscular injection of 1. 0- 2. 0 mg·kg- 1tramadol),flurbiprofen axetil group( 53 patients were given slow intravenous infusion of 0. 8- 1. 0 mg·kg- 1flurbiprofen axetil) and parecoxib sodium group( 53 patients were given slow intravenous infusion of 0. 6- 1. 0 mg·kg- 1parecoxib sodium). The resting visual simulation scale( VAS) score,motorial VAS score,mean arterial blood pressure( MAP),heart rate( HR),respiration rate( RR),arterial oxygen saturation( SpO2),and adverse reactions of the three groups 1,2,6,12 and 24 h after operation were compared and analyzed in the three groups. Results Resting and motorial VAS scores,MAP,HR and RR of flurbiprofen axetil and parecoxib sodium group were lower than tramadol group 1,2,6,12 and 24 h after operation( P 0. 05). The resting and motorial VAS scores of parecoxib sodium group were lower than those of flurbiprofen axetil group significantly( P 0. 05). The incidence rates of adverse reactions of flurbiprofen axetil and parecoxib sodium group were lower than tramadol group,while the rate of parecoxib sodium group was lower than flurbiprofen axetil group significantly( P 0. 05). Conclusion The analgesic effect of parecoxib sodium is better than tramadol and flurbiprofen axetil in patients with myasthenia gravis after thymectomy for its small dosage and low adverse reactions.