Comparison of preemptive analgesia with flubriprofen axetil and parecoxib sodium

Objective: To compare the preemptive analgesic efficacies of parecoxib sodium and flurbiprofen axetil.Methods: Sixty female patients(ASA Ⅰ~Ⅱ) who underwent gynecological laparoscopy were divided into three groups randomly(n=20 in each group).Before induction of anesthesia,parecoxib sodium,flurbiprofen axetil or 0.9% NaCl(control) was injected.The amount of anesthetic use was recorded.The serum IL-6 levels,blood pressure and heart rate were measured 30min before the induction(T1),30min(T2) and 60min(T3) after pneumoperitoneum,and 2h after the end of surgery(T4).The pain score was evaluated with visual analogue scale(VAS) and Bruggrmann comfort scale(BCS),and the incidence of adverse events was recorded within 24h after the surgery.Results: Compared with control group,the amount of anesthetic use was reduced in parecoxib sodium and flurbiprofen axetil groups.The serum IL-6 level was increased after operation in all groups,and the level was the highest at T3 and T4 in control group(P0.05).The VAS scores were lower in parecoxib sodium and flurbiprofen axetil groups than in control group at 2,6h after operation.The score was the lower in parecoxib sodium group than in other groups at 12h after operation(P0.05).Furthermore,the BCS score 12h after operations was higher in parecoxib sodium group than in control group,and the score at 2 and 6h after operation was also higher in flurbiprofen axetil group than in control group(P0.05).Conclusion: Both parecoxib sodium and flurbiprofen axetil have the adequate preemptive analgesic effect and anti-inflammatory effect;however,parecoxib sodium seems to be a better choice.