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The expression of P16 INK4A and MIB-1 in cervical cancer and cervical cancer lesion before

Mingming Xiao

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Abstract

Objective: To evaluate the expression of P16 INK4A and MIB-1 in cervical cancer and cervical cancer lesion before.Methods: Immunohistochemistry methods were used to detect the expression of P16 INK4A and MIB-1 in 63 cases of cervical tissue and 38 cases of cerical smear.Results: No positive staining of P16 was observed in the normal cervical epithelium.With increasing severity of cervical intraepithelial neoplasias(CIN),the P16 expression increased progressively,significant up-regulation of P16 was observed in carcinoma cervix.MIB-1 was observed with increasing severity of CIN,and significant overexpression of MIB-1 was observed in carcinoma cervix.The expression of MIB-1 was increased with consistently increasing of P16,there was a correlation between P16 and MIB-1 in cervical lesions organization.Conclusion: The overexpression of P16 and MIB-1 demonstrates that they can be used as a diagnostic marker for cervical lesions.Therefore,in the exact diagnosis of cervical lesions and cervical cancer,P16 and MIB-1 markers can be used as one of the diagnostic bases.

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Objective: To evaluate the expression of P16 INK4A and MIB-1 in cervical cancer and cervical cancer lesion before.Methods: Immunohistochemistry methods were used to detect the expression of P16 INK4A and MIB-1 in 63 cases of cervical tissue and 38 cases of cerical smear.Results: No positive staining of P16 was observed in the normal cervical epithelium.With increasing severity of cervical intraepithelial neoplasias(CIN),the P16 expression increased progressively,significant up-regulation of P16 was observed in carcinoma cervix.MIB-1 was observed with increasing severity of CIN,and significant overexpression of MIB-1 was observed in carcinoma cervix.The expression of MIB-1 was increased with consistently increasing of P16,there was a correlation between P16 and MIB-1 in cervical lesions organization.Conclusion: The overexpression of P16 and MIB-1 demonstrates that they can be used as a diagnostic marker for cervical lesions.Therefore,in the exact diagnosis of cervical lesions and cervical cancer,P16 and MIB-1 markers can be used as one of the diagnostic bases.

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Available abstract

Objective: To evaluate the expression of P16 INK4A and MIB-1 in cervical cancer and cervical cancer lesion before.Methods: Immunohistochemistry methods were used to detect the expression of P16 INK4A and MIB-1 in 63 cases of cervical tissue and 38 cases of cerical smear.Results: No positive staining of P16 was observed in the normal cervical epithelium.With increasing severity of cervical intraepithelial neoplasias(CIN),the P16 expression increased progressively,significant up-regulation of P16 was observed in carcinoma cervix.MIB-1 was observed with increasing severity of CIN,and significant overexpression of MIB-1 was observed in carcinoma cervix.The expression of MIB-1 was increased with consistently increasing of P16,there was a correlation between P16 and MIB-1 in cervical lesions organization.Conclusion: The overexpression of P16 and MIB-1 demonstrates that they can be used as a diagnostic marker for cervical lesions.Therefore,in the exact diagnosis of cervical lesions and cervical cancer,P16 and MIB-1 markers can be used as one of the diagnostic bases.

Key concepts: Medicine, Cervical cancer, Immunohistochemistry, Cervical intraepithelial neoplasia, Cervix, Lesion, Pathology, Cancer

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