The expression and significance of P16~(INK4A) in cerical cancer and cervical intraepithelial neoplasia tissues

Objective To investigate the P16INK4A protein in cervical carcinoma(cervical cancer CC) and adjacent tissues,cervical intraepithelial neoplasia(cervical intraepithelial neoplasia,CIN) and adjacent tissue lesion significance.Methods P16INK4A protein was detected in 23 cases of cervical cancer and adjacent tissues,71 cases of cervical intraepithelial neoplasia and tissue lesions,20 cases of normal cervical tissue using immunohistochemistry PV-9000.Results The cervical cancer and cervical intraepithelial neoplasia in P16INK4A protein with the deepening of cervical lesions,the positive rate increased gradually increasing intensity,the difference was statistically significant(P0.05);and P16INK4A expression in cervical cancer tissue and cervical intraepithelial lesion tissue and no expression in normal cervical tissue;P16INK4A protein expression in cervical cancer and tumor size,invasive depth and lymph node metastasis(P0.05),but with age,ethnic and histological grade(P0.05).Conclusion P16INK4A protein expression and the degree of cervical lesions,no lesion tissue expression,P16INK4A protein may be involved in cervical cancer.P16INK4A protein expression and tumor diameter,depth of invasion and lymph node metastasis,may be used as the evaluation of new biological indicators of prognosis in cervical cancers.