Effect of irbesartan combined with benazapril on rever sing left ventricular hypertrophy in patients with essential hypertension

Objective To study the effect s of irbesartan and benazapril used individually or in combination on reversing le ft ventricular hypertrophy(LVH) in patient with essential hypertension(EH).Methods A total of 112 patients with EH were divided randomly into t hree groups:irbesartan group(150mg qd,n=38),benazapril group(10 mg qd,n=37) and combined treatment group(irbesartan 150mg qd+b enazapril 10mg qd,n=37).If the blood pressure(BP)≥160/95mmHg w as remained after 3 weeks treatment,then the dosees doubled.Treatment lasted for 6 months.LVMI was measured by heart Doppler ultrasound before and after treatme nt.The blood pressure was recordedby ABPM at same time.Results (1)After 6 months,LVMI was significantly less than that before treatment in the three groups(P0.01).LVMI in the combined treatment group was l ess than that in the irbesartan and benazapril groups(P0.01).N o significant difference was found between irbesartan and benazapril groups(P0.05).(2)Before treatment,24h SBP and 24h DBP did not show signif icant difference respectively in the groups(P0.05).After 6 mon ths,24h SBP and 24h DBP decreased more obviously than those before treatment(P0.01),but did not show difference between the three groups(P0.05).Conclusion Irbesartan combined with benazap ril has additive effect on reversing LVH in patients with EH,and this additive e ffect do not associate with decreasing blood pressure.