Effect of irbesartan combined with felodipine on reversing left ventricular hypertrophy in patients with essential hypertension.

Objective To study the effects of irbesartan with felodipine on reversing left ventriclar hypertrophy(LVH)in patient with essential hypertension(EH).Methods Sixty patients with EH were divided randomly into two groups:the controlled group(felodipine 5mg/d,n=30)and the treatment group(irbesartan 150mg/d with felodipine 5mg/d,n=30).If the blood pressure160/95 mmHg was remained after two sweeks therapy,the dosage will be doubled and the therapy will be lasted for 6 months.Results Following therapy for 6 months,left ventricular mass index(LVMI)decreased significantly in the treatment group(P0.01).LVMI in the test group decreased more than that in the contrlled group(P0.01).There were no differences for the mean systolic pressure(DBP)and mean diastolic pressure(SBP)pre-therapy in two groups(P0.05).Following therapy for 6 months,SBP and DBP/24h decreased significantly(P0.01).but there were no difference between the two groups(P0.05).Conclusion The results suggest than irbesartan combined with felodipine is able to increase the effect on reversing LVH in patients with EH.