Influence of irbesartan on serum uric acid and left ventricular function in hypertension incorporated with hyperuricacidemia metabolism patients

Objective: To observe and analyze the influence of irbesartan in essential hypertension incorporated with hyperuricacidemia metabolism in the elderly patients and compare it with felodipine.Methods: 72 elderly patients with hypertension incorporated with hyperuricacidemia are divided randomly and averagely into irbesartan group(n=36) and felodipine group(n=36),and treated by 150 mg irbesartan or 5 mg felodipine once per day respectively for 8 weeks.Results: The total effective rates of decompression were 81% for the irbesartan group and 75% for the felodipine group,respectively.There was no significant difference in curative effect between the two groups(P0.05).Compared with pretreatment,the serum uric acid level was descented(-126±38)μmom/L(P0.01) in the irbesartan group and(-25±32)μmom/L(P0.05) in the felodipine group,there was significant difference between the two groups(P0.01).After 8 weeks treatment,the IVST,LVPWT and LVMI of LV function descented while LVEF of LV function ascended apparently(P0.01).There was significant difference between the two groups in IVST,LVPWT,LVMI and LVEF of LV function(P0.05).Conclusion: Irbesartan can reduce BP and UA effectively as well as improve left ventricular function.