Paroxetine vs.Clomipramine for Obsessive-compulsive Disorder:A Clinical Control Study

OBJECTIVE:To observe the curative effect and side effects of paroxetine vs.clomipramine in the treatment of obsessive-compulsive disorder.METHODS:60 patients with obsessive-compulsive disorder meeting the CCMD-3 diagnostic criteria were randomly assigned to receive either paroxetine or clomipramine for 8 weeks.YaleBrown Obsessive-compulsive Scale(Y-BOCS),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA) and the clinical 4-grade criteria were used to evaluate the clinical efficacy;and the Treatment Emergent Symptom Scale(TESS) was employed to evaluate the side effects at study entry and at the end of weeks 4 and 8 of treatment.RESULTS:There was no significant difference in clinical efficacy between the two groups(P 0.05).Paroxetine showed significantly less side effects than did clomipramine(P 0.01) and good drug tolerability.CONCLUSION:Paroxetine is as effective as clomipramine yet with less daily dose,simple administration and less side effects in the treatment of obsessive-compulsive disorder.