Comparative study of paroxetine and clomipramine in treatment of patients with refractory obsessive-compulsive disorder

Objective:To compare the efficacy and side effects of paroxetine and clomipramine in the treatment of patients with refractory obsessive-compulsive disorder(OCD). Method:Sixty patients were randomly divided into two groups treated with paroxetine and clomipramine respectively for 8 weeks.The efficacy and side effects were monitored with clinical evaluation,Yale-Brown obsessive compulsive scale (Y-BOCS) and treatment emergant symptoms scale (TESS). Results:Both paroxetine and clomipramine were effective to refractory OCD,and there was no significant difference between two groups.But paroxetine was more effective to obsessive behavior and had less side effects. Conclusion:Paroxetine is a more suitable drug for treating with patients with refractory obsessive-compulsive disorder,especially for the patients with compulsive behavior.