Research on the changes of serum TNF-α,IL-6 and IL-8 levels in patients with bronchial asthma

Objective To observe the changes of serum TNF-α,IL-6 and IL-8 levels in patients with bronchial asthma and to explore the role of TNF-α,IL-6 and IL-8 in the development of the disease.Methods The enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of serum TNF-α,IL-6 and IL-8 for the patients of the bronchial asthma acute exacerbation group,the asthma remission group and the control group,and then their differences and correlation were analyzed.Results The levels of TNF-α,IL-6 and IL-8 of bronchial asthma patients were significantly higher than those of the control group(P 0.05),and positively correlation were existed among the three cytokines significantly(P 0.05).Conclusion The levels of serum TNF-α,IL-6 and IL-8 in patients with bronchial asthma are higher than the normal,which are impacted by the severity of the disease,and the three cytokines are likely involved in the inflammatory response of asthma.