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2013•China Modern MedicineRequires access

Research on the changes of serum cytokine levels in patients with bronchial asthma

YE Ju-zhe

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Abstract

Objective To explore the changes of serum cytokine levels in patients with bronchial asthma. Methods The enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of serum TNF- α,IL-6,IL-8 for the patients of the bronchial asthma acute exceration group,asthma remission group and the control group,and detect the data of FEV1/FVC for them. Results The levels of TNF-a,IL-6,IL-8 of bronchial asthma patients in acute exceration group were obviouslyhigher than asthma remission group and control group(P0.05);The levels of TNF-α,IL-6,IL-8 in asthma remission group were significantlyhigher than control group( P0.05).The levels of TNF-α,IL-6,IL-8 were negatively correlated to the data of FEV1/FVC in bronchial asthma. Conclusion The levels of TNF-α,IL-6,IL-8 are involved in the inflammatory reation of bronchial asthma,can be used as judgement index of patients with bronchial asthma disease severity.

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Objective To explore the changes of serum cytokine levels in patients with bronchial asthma. Methods The enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of serum TNF- α,IL-6,IL-8 for the patients of the bronchial asthma acute exceration group,asthma remission group and the control group,and detect the data of FEV1/FVC for them. Results The levels of TNF-a,IL-6,IL-8 of bronchial asthma patients in acute exceration group were obviouslyhigher than asthma remission group and control group(P0.05);The levels of TNF-α,IL-6,IL-8 in asthma remission group were significantlyhigher than control group( P0.05).The levels of TNF-α,IL-6,IL-8 were negatively correlated to the data of FEV1/FVC in bronchial asthma. Conclusion The levels of TNF-α,IL-6,IL-8 are involved in the inflammatory reation of bronchial asthma,can be used as judgement index of patients with bronchial asthma disease severity.

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Available abstract

Objective To explore the changes of serum cytokine levels in patients with bronchial asthma. Methods The enzyme-linked immunosorbent assay(ELISA) was used to detect the levels of serum TNF- α,IL-6,IL-8 for the patients of the bronchial asthma acute exceration group,asthma remission group and the control group,and detect the data of FEV1/FVC for them. Results The levels of TNF-a,IL-6,IL-8 of bronchial asthma patients in acute exceration group were obviouslyhigher than asthma remission group and control group(P0.05);The levels of TNF-α,IL-6,IL-8 in asthma remission group were significantlyhigher than control group( P0.05).The levels of TNF-α,IL-6,IL-8 were negatively correlated to the data of FEV1/FVC in bronchial asthma. Conclusion The levels of TNF-α,IL-6,IL-8 are involved in the inflammatory reation of bronchial asthma,can be used as judgement index of patients with bronchial asthma disease severity.

Key concepts: Medicine, Asthma, Cytokine, Immunology, Internal medicine, Tumor necrosis factor alpha, Gastroenterology

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