2012•Practical Journal of Cardiac Cerebral Pneumal and Vascular DiseaseRequires access

Effect of Atorvastatin on Serum IL-18,MMP2 in Patients with Acute Coronary Syndrome

Yan Quan-nen

Abstract

Objective To explore the effect of atorvastatin on serum levels of IL-18、MMP2 in patients with acute coronary syndrome(ACS).Methods ACS group(n=86)and stable angina pectoris(SAP)group(n=40).40 individuals with normal coronary angiography were selected as control group.At the same time,86 patients with ACS were randomly divided into atorvastatin group(n=43)and conventional-treated group(n=43).Serum levels of IL-18、MMP2 were measured by enzyme-linked immunosorbent assay(ELISA).The change of serum IL-18、MMP2 levels was compared among the groups.Results Serum levels of IL-18、MMP2 in ACS group were significantly higher than those in SAP group and control group(P0.05).After the treatment,serum levels of IL-18、MMP2 in atorvastatin group and conventional-treated group were significantly decreased compared with those in the two groups before the treatment(P0.05).Conclusion Atorvastatin can decrease serum IL-18、MMP2 levels in patients with ACS,which contributes to suppression of inflammation response and matrix degradation,to advance the stability of atherosclerosis plaque and lower the rate of acute coronary syndrome.

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Key concepts: Medicine, Acute coronary syndrome, Atorvastatin, MMP2, Stable angina, Unstable angina, Internal medicine, Gastroenterology