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2007•China Practical MedicineRequires access

Effect of Atorvastatin on serum matrix metalloproteinases-9 level in patients with acute coronary syndrome

Wang Xua

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Abstract

Objective To observe the influence of Atorvastatin on serum matrix matalloproteiases-9(MMP-9)level in patients with acute coronary syndrome(ACS).Methods 30 healthy people were the control group and 60 ACS patients were the Atorvastatin treatment group.The serum levels of MMP-9 before and after treatment were detected.Results The patients of the Atorrastatin treatment group had higher levels of MMP-9 compared with those of the control group(P0.001).After 2 weeks of Atorvastatin treatment,the levels of serum MMP-9 in the Atorvastatin treatment group were significantly decreased(P0.001).Conclusion Atorvastatin decreases serum level of inflammatory factors in the patients with ACS,so it maybe benefit to atherosclerotic plaque stabilization.

About this research paper

What this paper is about

Objective To observe the influence of Atorvastatin on serum matrix matalloproteiases-9(MMP-9)level in patients with acute coronary syndrome(ACS).Methods 30 healthy people were the control group and 60 ACS patients were the Atorvastatin treatment group.The serum levels of MMP-9 before and after treatment were detected.Results The patients of the Atorrastatin treatment group had higher levels of MMP-9 compared with those of the control group(P0.001).After 2 weeks of Atorvastatin treatment,the levels of serum MMP-9 in the Atorvastatin treatment group were significantly decreased(P0.001).Conclusion Atorvastatin decreases serum level of inflammatory factors in the patients with ACS,so it maybe benefit to atherosclerotic plaque stabilization.

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Available abstract

Objective To observe the influence of Atorvastatin on serum matrix matalloproteiases-9(MMP-9)level in patients with acute coronary syndrome(ACS).Methods 30 healthy people were the control group and 60 ACS patients were the Atorvastatin treatment group.The serum levels of MMP-9 before and after treatment were detected.Results The patients of the Atorrastatin treatment group had higher levels of MMP-9 compared with those of the control group(P0.001).After 2 weeks of Atorvastatin treatment,the levels of serum MMP-9 in the Atorvastatin treatment group were significantly decreased(P0.001).Conclusion Atorvastatin decreases serum level of inflammatory factors in the patients with ACS,so it maybe benefit to atherosclerotic plaque stabilization.

Key concepts: Atorvastatin, Medicine, Matrix metalloproteinase, Acute coronary syndrome, Internal medicine, Gastroenterology, Matrix metalloproteinase 9, Myocardial infarction

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Effect of Atorvastatin on serum matrix metalloproteinases-9 level in patients with acute coronary syndrome — Research Paper | ScholarLens