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2006•Henan yixue yanjiuRequires access

The effect of atorvastatin on serum level of matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinase-2 in patients with acute coronary syndromes

Zhaoke Wu

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Abstract

Objective: To investigate the influences of atorvastatin on serum MMP2,TIMP-2 and MMP-2/TIMP-2 levels of patients with acute coronary syndrome(ACS).Methods: There were 51 patients with ACS and 15 patients with SA.Meanwhile,20 cases of age matched control individuals were selected.Then 51 patients with ACS were randomly divided into two groups: Atorvastatin treatment group and regular treatment group.The serum level of MMP-2 and TIMP-2 were compared among all groups.Results: There was significant difference in serum level of MMP-2 and TIMP-2 between ACS group and SA group and control group.There was significant difference in serum level of MMP-2 and TIMP-2 between atorvastatin treatment group and regular treatment group after treatment.Conclusion: atorvastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction,and it might have a beneficial effect on steadying the plaque.

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What this paper is about

Objective: To investigate the influences of atorvastatin on serum MMP2,TIMP-2 and MMP-2/TIMP-2 levels of patients with acute coronary syndrome(ACS).Methods: There were 51 patients with ACS and 15 patients with SA.Meanwhile,20 cases of age matched control individuals were selected.Then 51 patients with ACS were randomly divided into two groups: Atorvastatin treatment group and regular treatment group.The serum level of MMP-2 and TIMP-2 were compared among all groups.Results: There was significant difference in serum level of MMP-2 and TIMP-2 between ACS group and SA group and control group.There was significant difference in serum level of MMP-2 and TIMP-2 between atorvastatin treatment group and regular treatment group after treatment.Conclusion: atorvastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction,and it might have a beneficial effect on steadying the plaque.

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Available abstract

Objective: To investigate the influences of atorvastatin on serum MMP2,TIMP-2 and MMP-2/TIMP-2 levels of patients with acute coronary syndrome(ACS).Methods: There were 51 patients with ACS and 15 patients with SA.Meanwhile,20 cases of age matched control individuals were selected.Then 51 patients with ACS were randomly divided into two groups: Atorvastatin treatment group and regular treatment group.The serum level of MMP-2 and TIMP-2 were compared among all groups.Results: There was significant difference in serum level of MMP-2 and TIMP-2 between ACS group and SA group and control group.There was significant difference in serum level of MMP-2 and TIMP-2 between atorvastatin treatment group and regular treatment group after treatment.Conclusion: atorvastatin could decrease the breakdown of matrix collagen and reduce inflammatory reaction,and it might have a beneficial effect on steadying the plaque.

Key concepts: Atorvastatin, Medicine, Matrix metalloproteinase 9, Matrix metalloproteinase, MMP2, Acute coronary syndrome, Internal medicine, Gastroenterology

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The effect of atorvastatin on serum level of matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinase-2 in patients with acute coronary syndromes — Research Paper | ScholarLens