The expression and relationship of HIF-lα,Caspase-3,and Survivin in esophageal squamous cell carcinoma

Objective To explore the relationship between the expressions of HIF-lα,Caspase-3,Survivin proteins and the occurrence and development of esophageal squamous cell carcinoma.Methods The expressions of HIF-lα,Caspase-3,Survivin protein were detected in 49 cases of esophageal squamous cell carcinoma,and cancer-adjacent mucosa tissues(including normal epithelium,simple hyperplasia epithelium,mild atypical hyperplasia epithelium,severe atypical hyperplasia epithelium, carcinoma in situ) by streptomycete avidin peroxides(SP) immunohistochemistry.Results There were increasing trade in the positive rates of HIF-lα,Survivin protein from normal epithelium,simple hyperplasia epithelium,mild atypical hyperplasia epithelium,severe atypical hyperplasia epithelium,carcinoma in situ to invasive carcinoma,and there were significant differences between the normal epithelium and the invasive carcinoma(P0.05).There were decreasing trade in the positive rates of Caspase-3 protein from normal epithelium,simple hyperplasia epithelium,mild atypical hyperplasia epithelium,severe atypical hyperplasia epithelium,carcinoma in situ to invasive carcinoma,and there were significant differences between the normal epithelium and the invasive carcinoma(P0.05).There was a positive correlation between the positive expression rate of HIF-lα protein and the that of Survivin protein,and a negative correlation between the positive expression rate of HIF-lα protein and the that of Caspase-3 protein in esophageal squamous cell carcinoma(P0.05).Conclusion The over expression of HIF-lα,Survivin protein and decrease expression of Caspase-3 protein can play important roles in the occurrence and development of esophageal squamous cell carcinoma.The expression of HIF-lα protein can decrease the expression of Caspase-3 protein,accordingly,increasing the expression of Survivin protein.